GuidelinesfortheSelectionofAnti-infectiveAgents forComplicatedIntra-abdominalInfections

JosephS.Solomkin, JohnE.Mazuski, EllenJ.Baron, RobertG.Sawyer, AveryB.Nathens, JosephT.DiPiro,TimothyBuchman, E.PatchenDellinger, JohnJernigan, SherwoodGorbach, AnthonyW.Chow,andJohnBartlett DepartmentofSurgery,UniversityofCincinnatiCollegeofMedicine,Cincinnati,Ohio; DepartmentofSurgery,WashingtonUniversitySchool ofMedicine,St.Louis,Missouri; DepartmentofMicrobiology,StanfordUniversitySchoolofMedicine,PaloAlto,California; Department ofSurgery,UniversityofVirginia,Charlottesville; DepartmentofSurgery,UniversityofWashington,Seattle; UniversityofGeorgiaCollege ofPharmacy, DepartmentofSurgery,MedicalCollegeofGeorgia,Augusta,and CentersforDiseaseControlandPrevention,Atlanta;DepartmentofMedicine,TuftsUniversitySchoolofMedicine,Boston,

Massachusetts;DepartmentofMedicine,JohnsHopkinsUniversitySchoolofMedicine,Baltimore,Maryland;

andDepartmentofMedicine,UniversityofBritishColumbia,Vancouver,BritishColumbia,Canada

EXECUTIVESUMMARY

Theseguidelines,fromtheInfectiousDiseasesSociety ofAmerica(IDSA),theSurgicalInfectionSociety,the AmericanSocietyforMicrobiology,andtheSocietyof InfectiousDiseasePharmacists,containevidence-based recommendationsforselectionofantimicrobialtherapy foradultpatientswithcomplicatedintra-abdominalin-fections.Complicatedintra-abdominalinfectionsex-tendbeyondthehollowviscusoforiginintotheperi-tonealspaceandareassociatedeitherwithabscess formationorwithperitonitis.Theseguidelinesalsoad-dresstimingofinitiationofantibiotictherapy,when andwhattoculture,modi?cationoftherapybasedon cultureresults,anddurationoftherapy.

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